Search vacation rentals in Saint Helena Island, SC from 100+ sites!

1139 available vacation rental offers

7 nights
2
1
  • airbnb
  • booking
  • vrbo
  • expedia
  • sonder
  • priceline
  • tripadvisor
  • tripcom
  • homestay
  • hotelscom
  • orbitz
  • vacasa
Saint Helena Island, SC vacation rentals
Choose the perfect vacation accommodation
Price per night
Accommodation type
Rating

Saint Helena Island, SC Vacation rentals: no available offers. Here are other great options for your stay!

Cozy & Quiet 4 Four. Pets Yes! - Saint Helena Island, SC
10 1 review
Saint Helena Island, SC
06/29 – 07/04
$170/nightTotal: $850 (5 )

Cozy & Quiet 4 Four. Pets Yes!

1 4
apartment , Beaufort
This Beaufort vacation rental is centrally located near the John Mark Verdier House and Thomas Hepworth House, providing easy access to Henry C. Chambers Waterfront Park and Port Royal Skateboard Park.
This pet-friendly apartment boasts 400 square feet of space, featuring one bedroom, one bathroom, and amenities including a fully equipped kitchen, air conditioning, a terrace, and parking, comfortably accommodating up to four guests.
Family-friendly Home. Pets Yes! - Saint Helena Island, SC
9.6 4 reviews
Saint Helena Island, SC
06/29 – 07/04
$243/nightTotal: $1215 (5 )

Family-friendly Home. Pets Yes!

3 4
apartment , Beaufort
This newly renovated apartment on Lady's Island is a 4-minute drive from shops and restaurants and 7 minutes from downtown Beaufort, offering easy access to attractions like the John Mark Verdier House and the Port Royal Farmers Market.
This 910-square-foot rental boasts a 1-bedroom, 2-bathroom layout sleeping 6, features a fully fenced backyard, smart lock, and includes a dishwasher, microwave, and air conditioning.
Home In Beaufort Historic District W/ Private Yard - Saint Helena Island, SC
9.8 10 reviews
Saint Helena Island, SC
06/29 – 07/04
$325/nightTotal: $1625 (5 )

Home In Beaufort Historic District W/ Private Yard

3 4
apartment , Beaufort
This Beaufort Historic District vacation rental is a short walk from St. Helena's Episcopal Church, the University of South Carolina Beaufort, and the USCB Center for the Arts, with Bay Street and the Beaufort Museum also nearby.
This 1150-square-foot house features three bedrooms, two bathrooms, and can comfortably accommodate six guests, offering a fully equipped kitchen, laundry facilities, a patio, and a garden.
Parris Island Marine Corps Graduation Pcs Orders Travel Nurses Beaufort Home - Saint Helena Island, SC
9.6 69 reviews
Saint Helena Island, SC
06/29 – 07/04
$197/nightTotal: $985 (5 )

Parris Island Marine Corps Graduation Pcs Orders Travel Nurses Beaufort Home

2 4
apartment , Beaufort
This two-bedroom townhome in Beaufort is conveniently located within walking distance to Spanish Moss Trail, Sands Beach, and Downtown Beaufort. It has excellent user ratings and is ideal for up to six guests.
The apartment has a floor area of 1160 square feet and features a fully stocked kitchen, comfortable living area, and two spacious bedrooms. Guests can enjoy amenities such as a 65" Roku TV with DirecTV, Wi-Fi, outdoor security cameras, and complimentary toiletries.

Frequently Asked Questions about vacation rentals in Saint Helena Island, SC

Destinations nearby

©2026 cozycozy.com